Mem Inst Oswaldo Cruz, Rio de Janeiro, FAST TRACK
Short communication

Comorbidities increase in-hospital mortality in dengue patients in Brazil

Guilherme L. Werneck1,+, Alejandro E. Macias2, Cesar Mascarenas3, Laurent Coudeville3, David Morley4, Vincent Recamier4, Mariana Guergova-Kuras4, Esteban Puentes-Rosas5, Nicolas Baurin3, Myew-Ling Toh3

1Instituto de Estudos em Saúde Coletiva, Universidade Federal do Rio de Janeiro, Rio de Janeiro RJ, Brasil
2Área De Microbiología, Departamento De Medicina, Universidad de Guanajuato, Guanajuato, Mexico
3Sanofi Pasteur, Lyon, France
4Ariana Pharmaceuticals, Paris, France
5Sanofi Pasteur, Mexico

DOI: 10.1590/0074-02760180082
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ABSTRACT

Dengue remains an unmet public health burden. We determined risk factors for dengue in-hospital mortality in Brazil. Of 326,380 hospitalized dengue cases in 9–45 years old individuals, there were 971 deaths. Risk of dying was 11 times higher in the presence of underlying common comorbidities (renal, infectious, pulmonary disease and diabetes), similar to the risk of dying from severe dengue and much higher with the combination. Ensuring access to integrated dengue preventative measures in individuals ≥9 years including those with comorbidities may help achieve the WHO objective of 50% reduction in mortality, 25% reduction in morbidity to dengue by 2020.

+ Corresponding author: gwerneck@iesc.ufrj.br

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