Mem Inst Oswaldo Cruz, Rio de Janeiro, FAST TRACK NOT PUBLISHED
Original Article

First Detection of natural infection of yellow fever virus in Aedes albopictus in Brazil

Lívia C Martin1*, Ana CR Cruz1*, Leonardo H Hernandez1, Sandro P Silva1, Marta Lívia C Martin1*, Ana CR Cruz1*, Leonardo H Hernandez1, Sandro P Silva1, Marta Giovanetti2, Jaqueline Goes de Jesus2, Julian Theze3, Ana MB de Filippis4, Luiz CJ Alcantara2,4, Raimunda SS Azevedo1, Joaquim P Nunes Neto1, Pedro HO Passos5, Marco AB Almeida6, Daniel G Ramos5, Alessandro PM Romano5, Mariana G de Brito7, Fabiano dos AP Martins8, Daniele BA Medeiros1, Jannifer O Chiang1,+, Pedro FC Vasconcelos1

1Department of Arbovirology and Hemorrhagic fevers, Instituto Evandro Chagas, Instituto Evandro Chagas,Ananindeua, Pará, Brazil

2Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Bahia, Brazil

3Department of Zoology, University of Oxford, Oxford, United Kingdom

4Flavivirus Laboratory, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil

5Arbovirus Surveillance Group, Department of Surveillance of Communicable Diseases, Secretariat of Health Surveillance, Ministry of Health, Brazil

6Health Surveillance Center, Rio Grande do Sul State Health Department

7Health Surveillance Center, Minas Gerais State Health Department

8Health Superintendence of Coronel Fabriciano, Minas Gerais State Health Department

DOI: 10.1590/0074- 02760180444
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ABSTRACT

During the 2016-2017 yellow fever outbreak in Brazil, mosquitoes were captured in sylvatic and peri-urban areas in Minas Gerais state, Brazil. RT-qPCR was performed to detect yellow fever virus (YFV) in pools of Aedes sp., Sabethes sp. and Haemagogus sp. mosquitoes, followed by next generation sequencing. Besides the Haemagogus jantinomys that have been related as mainly vector in this outbreak, here we are showing the first natural detection of YFV (South American genotype I) in Aedes albopictus mosquitoes. Indeed, the Asian tiger also showed the second higher capture and positivity rates. This finding reinforces hypothesis that Ae. albopictus may act as “bridge-vector”, in an intermediary cycle, increasing the risk of re-urbanization of YF.

+ Corresponding author: janniferchiang@iec.gov.br

*These authors have contributed equally to this study

Accession number: The nucleotide sequence determined in this study have been deposited in GenBank under the accession number MH329655.

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