MEM INST OSWALDO CRUZ, RIO DE JANEIRO, Vol. 112 | 2017
PAGES: DOI: 10.1590/0074-02760160355 Short communication
The use of circulating cathodic antigen rapid test and serology for diagnosis of active Schistosoma mansoni infection in migrants in Italy, a non-endemic country: a cross sectional study

Laura Infurnari1, Laura Galli2, Alba Bigoloni2, Alessia Carbone2, Stefania Chiappetta2, Angelo Sala3, Norberto Ceserani2, Adriano Lazzarin2,4, Antonella Castagna2,4, Giovanni Gaiera2+

1San Raffaele Scientific Institute, Laboratory of Microbiology and Virology, Milan, Italy
2San Raffaele Scientific Institute, Infectious Diseases Department, Milan, Italy
3Saint Michel Centre, Society of Priests of the Sacred Heart of Betharram, Health Pastoral Diocese of Bouar, Bouar, Central African Republic
4Università Vita-Salute San Raffaele, Milan, Italy

Abstract

Diagnosis of schistosomiasis in migrants coming from endemic areas can be difficult, especially in asymptomatic subjects. Light-intensity disease, in fact, may be missed due to the low sensitivity of the stool microscopy and serologic testing cannot distinguish between a resolved infection and an active infection in patients who have been infected and treated in the past, because specific antibodies can persist despite cure. We describe a cross-sectional study conducted on 82 migrants tested for Schistosoma mansoni on single blood (anti-schistosome antibodies, total IgE) and urine [point-of-care (POC) circulating-cathodic-antigen (CCA) test] samples. A positive POC-CCA test (active infection) resulted in two untreated patients with a positive serology while all patients (n = 66) with a past infection showed a negative POC-CCA test. POC-CCA urine test in combination with serology may be helpful in rapidly differentiate active from past S. mansoni infection in migrants coming from endemic areas.

+ Corresponding author: This e-mail address is being protected from spambots. You need JavaScript enabled to view it.
Received 7 August 2016
Accepted 4 March 2017

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