MEM INST OSWALDO CRUZ, RIO DE JANEIRO, FAST TRACK
PAGES: DOI: 10.1590/0074-02760170299 Letter to the editor
TRACING THE ORIGIN OF THE NS1 A188V SUBSTITUTION RESPONSIBLE FOR RECENT ENHANCEMENT OF ZIKA VIRUS ASIAN GENOTYPE INFECTIVITY

Edson Delatorre1, Daiana Mir1 and Gonzalo Bello1+

1Laboratório de AIDS e Imunologia Molecular, Instituto Oswaldo Cruz, Fiocruz, Rio de Janeiro, Brazil

Abstract

A recent study showed that infectivity of Zika virus (ZIKV) Asian genotype was enhanced by an alanine-to-valine amino acid substitution at residue 188 of the NS1 protein, but the precise time and location of origin of this mutation were not formally estimated. Here, we applied a Bayesian coalescent-based framework to estimate the age and location of the ancestral viral strain carrying the A188V substitution. Our results showed that the ancestral ZIKV strain carrying the A188V substitution probably arose in Southeastern Asia and circulated in that region for some time (5-10 years) before being disseminated to Southern Pacific islands and the Americas.

+ Corresponding author: Lab. de AIDS & Imunologia Molecular, Instituto Oswaldo Cruz - FIOCRUZ. Av. Brasil 4365, Manguinhos, 21040-360, Rio de Janeiro, RJ, Brazil. Phone: +55 21 3865 8154. E-mail: This e-mail address is being protected from spambots. You need JavaScript enabled to view it.  / This e-mail address is being protected from spambots. You need JavaScript enabled to view it.

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