MEM INST OSWALDO CRUZ, RIO DE JANEIRO, FAST TRACK
PAGES: DOI: 10.1590/0074-02760170389 Full paper
EPIZOOTIC DUE TO YELLOW FEVER VIRUS IN SAO PAULO STATE: PRELIMINARY EPIDEMIOLOGICAL AND PHYLOGENETIC DATA AND VIRAL DISSEMINATION TO NEW AREAS (2016-2017)

Mariana Sequetin Cunha1, Antônio Charlys da Costa4, Natália Coelho Couto de Azevedo Fernandes2, Juliana Mariotti Guerra2, Fabiana Cristina Pereira dos Santos1, Juliana Silva Nogueira1, Iray Maria Rocco1, Leandro Guariglia D' Agostino1, Shirley Cavalcante Vasconcelos Komninakis4,5, Adriana Yurika Maeda1, Fernanda Gisele Silva Vasami1, Laís Sampaio1, Paloma Alana Facioli1, Fernando Luiz Macedo, Ester Cerdeira Sabino2, Renato Pereira de Sousa1

1Núcleo de Doenças de Transmissão Vetorial, Centro de Virologia, Instituto Adolto Lutz, São Paulo, Brasil
2Centro de Patologia, Instituto Adolto Lutz, São Paulo, Brasil
3Department of Infectious Disease, School of Medicine & Institute of Tropical Medicine, University of São Paulo, Brazil
4Retrovirology Laboratory, Federal University of São Paulo, Brazil
5School of Medicine of ABC (FMABC), Clinical Immunology Laboratory, Santo Andre, Brazil

Abstract

Yellow Fever virus is an RNA virus that belongs to family Flaviviridae, genus Flavivirus. In humans, yellow fever may vary from inapparent to a fatal disease, with patients presenting fever, prostration, hepatic, renal and myocardial injury, hemorrhage and shock. In Brazil, the virus is maintained by a sylvatic transmission cycle involving non-human primates and forest canopy-dwelling mosquitoe. Urban yellow fever was erradicated in 1942. This is a preliminary descriptive study encompassing epizootic events between July 2016 and March 2017, in São Paulo State, Brazil. Fresh and fixed tissues and tissues fixed in 10% neutral buffered formalin from NHP found dead or serum from live animals were sent to Adolfo Lutz Institute, São Paulo, for YFV molecular detection and immunohistochemistry. A total of 67 NHP were YFV positive during this time. Until December 2016, only cities within the vaccine recommendation area reported epizootic events due to YFV. However, in the beggining of 2017, YFV was detected in areas not deemed to be at risk for yellow fever. A Phylogenetic analysis showed similarity between the current epizootic with the past one, occured in 2008. This work shows the importance of NHP surveillance in order to initiate quickly the vaccination in local susceptible population.

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