Mem Inst Oswaldo Cruz, Rio de Janeiro, VOLUME 115 | FEBRUARY 2020
Original Article

Mapping the tuberculosis scientific landscape among BRICS countries: a bibliometric and network analysis

Kamaiaji Castor1, Fabio Batista Mota1, Roseli Monteiro da Silva1, Bernardo Pereira Cabral1, Ethel Leonor Maciel2, Isabela Neves de Almeida3/+, Denise Arakaki-Sanchez4, Kleydson Bonfim Andrade4, Vadim Testov5, Irina Vasilyeva5, Yanlin Zhao6, Hui Zhang6, Manjula Singh7, Raghuram Rao8, Srikanth Tripathy9, Glenda Gray10, Nesri Padayatchi10, Niresh Bhagwandin10, Soumya Swaminathan11,13, Tereza Kasaeva11,13, Afrânio Kritski12

1Fundação Oswaldo Cruz-Fiocruz, Centro de Estudos Estratégicos, Rio de Janeiro, RJ, Brasil
2Universidade Federal do Espírito Santo, Laboratório de Epidemiologia, Vitória, ES, Brasil
3Universidade Federal de Minas Gerais, Faculdade de Medicina, Laboratório de Pesquisa em Micobactérias, Belo Horizonte, MG, Brasil
4Ministério da Saúde, Programa Nacional de Controle da Tuberculose, Brasília, DF, Brasil
5National Medical Research Centre of Pthtisiopulmonology and Infection Diseases, MoH, Moscow, Russian Federation
6National Centre for Tuberculosis Control and Prevention, China CDC, Changping District, Beijing, China
7Indian Council of Medical Research, New Delhi, India
8Government of India, Ministry of Health and Family Welfare Central TB Division, New Delhi, India
9National Institute for Research in Tuberculosis, Chennai, India
10University of KwaZulu-Natal, Doris Duke Medical Research Institute, South African Medical Research Council HIV–TB Pathogenesis  and Treatment Research Unit, Congella, South Africa
11Phthisiology, Central TB Research Institute, Moscow, Russian Federation
12Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Programa Acadêmico de Tuberculose, Rio de Janeiro, RJ, Brasil
13World Health Organization, Geneva, Switzerland

DOI: 10.1590/0074-02760190342
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BACKGROUND The five BRICS (Brazil, Russian, Indian, China, and South Africa) countries bear 49% of the world’s tuberculosis (TB) burden and they are committed to ending tuberculosis.

OBJECTIVES The aim of this paper is to map the scientific landscape related to TB research in BRICS countries.

METHODS Were combined bibliometrics and social network analysis techniques to map the scientific publications related to TB produced by the BRICS. Was made a descriptive statistical data covering the full period of analysis (1993-2016) and the research networks were made for 2007-2016 (8,366 records). The bubble charts were generated by VantagePoint and the networks by the Gephi 0.9.1 software (Gephi Consortium 2010) from co-occurrence matrices produced in VantagePoint. The Fruchterman-Reingold algorithm provided the networks’ layout.

FINDINGS During the period 1993-2016, there were 38,315 peer-reviewed, among them, there were 11,018 (28.7%) articles related by one or more authors in a BRICS: India 38.7%; China 23.8%; South Africa 21.1%; Brazil 13.0%; and Russia 4.5% (The total was greater than 100% because our criterion was all papers with at least one author in a BRICS). Among the BRICS, there was greater interaction between India and South Africa and organisations in India and China had the highest productivity; however, South African organisations had more interaction with countries outside the BRICS. Publications by and about BRICS generally covered all research areas, especially those in India and China covered all research areas, although Brazil and South Africa prioritised infectious diseases, microbiology, and the respiratory system.

MAIN CONCLUSIONS An overview of BRICS scientific publications and interactions highlighted the necessity to develop a BRICS TB research plan to increase efforts and funding to ensure that basic science research successfully translates into products and policies to help end the TB epidemic.

01. United Nations General Assembly. Transforming our world: the 2030 agenda for sustainable development [cited 2019 September 10]. 2015. Available from:
02. Uplekar M, Weil D, Lonnroth K, Jaramillo E, Lienhardt C, Dias HM, et al. WHO’s new end TB strategy. Lancet. 2015; 385(9979): 1799-801.
03. WHO - World Health Organization. A global action framework for TB research in support of the third pillar of WHO’s end TB strategy [cited 2019 Septmber 10]. 2015. Available from:
04. Pai M. Time for high-burden countries to lead the tuberculosis research agenda. PLoS Med. 2018; 15(3): 10-2.
05. United Nations General Assembly. Political declaration of the high-level meeting of the General Assembly on the fight against tuberculosis [73/3]. [cited 2019 September 10]. 2018. Available from:
06. WHO - World Health Organization. Global investments in tuberculosis research and development: past, present, and future. [cited 2019 September 10]. Available from:
07. Kirton J, Larionova M, Alagh Y E. BRICS New Delhi Summit. [Internet]. [cited 2019 September 10]. 2012. Available from:
08. Xiaodong W. Tianjin to host 7th BRICS Health Ministers Meeting. 2017. [cited 2019 September 10]. Available from:
09. Raviglione M, Uplekar M, Weil D, Kasaeva T. Tuberculosis makes it onto the international political agenda for health…finally. Lancet Glob Heal. 2018; 6(1): e20-1.
10. Nafade V, Nash M, Huddart S, Pande T, Gebreselassie N, Lienhardt C, et al. A bibliometric analysis of tuberculosis research, 2007-2016. PLoS One. 2018; 13(6): e0199706.
11. González-Albo B, Bordons M. Articles vs. proceedings papers: do they differ in research relevance and impact? A case study in the library and information science field. J Informetr. 2011; 5(3): 369-81.
12. Kochi A. Tuberculosis as a global emergency. Vol. 71. Kekkaku: 1996. p. 319-28.
13. Santoro N, Quattrociocchi W, Flocchini P, Casteigts A, Amblard F. Time-varying graphs and social network analysis: temporal indicators and metrics. In: 3rd AISB Social Networks and Multiagent Systems Symposium [Internet]. 2011. Available from:
14. Freeman LC. Centrality in social networks conceptual clarification. Soc Networks. 1978; 1(3): 215-39.
15. Wasserman S, Faust K. Social network analysis: methods and applications. Vol.1. New York: Cambridge University Press; 1994. 825 pp.
16. Golbeck J. Analyzing the social web. Vol.1. Waltham: Elsevier Inc.; 2013. 264 pp.
17. Blondel VD, Guillaume J, Lefebvre E. Fast unfolding of communities in large networks. J Stat Mech Theory Exp. 2008; 10: 1-12.
18. Gephi. The Open Graph Viz Platform. 2010.
19. Golbeck J. Analyzing the social web. 1st ed. Waltham: Elsevier Inc. 2013.
20. Jacomy M, Venturini T, Heymann S, Bastian M. ForceAtlas2, a continuous graph layout algorithm for handy network visualisation designed for the Gephi software. PLoS One. 2014; 9(6): e98679.
21. Gorin SV, Koroleva AM, Ovcharenko NA. The Russian science citation index (RSCI) as a new trend in scientific editing and publishing in Russia. Eur Sci Ed. 2016; 42(3): 60-2.
22. Atkins S, Marsden S, Diwan V, Zwarenstein M. North-south collaboration and capacity development in global health research in low- and middle-income countries - The ARCADE projects. Glob Health Action. 2016; 9(1): 1-9.
23. Lienhardt C, Espinal M, Pai M, Maher D, Raviglione MC. What research is needed to stop TB? Introducing the TB research movement. PLoS Med. 2011; 8(11): 1-6.
24. Vasconcellos AG, Morel CM. Enabling policy planning and innovation management through patent information and co-authorship network analyses: a study of tuberculosis in Brazil. PLoS One. 2012; 7(10): e45569.
25. Fonseca BPFE, Silva MVPD, Araújo KM, Sampaio RB, Moraes MO. Network analysis for science and technology management: evidence from tuberculosis research in Fiocruz, Brazil. PLoS One. 2017; 12(8): e0181870.
26. Sweileh WM, AbuTaha AS, Sawalha AF, Al-Khalil S, Al-Jabi SW, Zyoud SH. Bibliometric analysis of worldwide publications on multi-, extensively, and totally drug - resistant tuberculosis (2006-2015). Multidiscip Respir Med. 2016; 11(45): 1-16.
27. Mike Brennan, Cobelens F, Lanfranchi B, Lienhardt C, Sizemore C, Waltz G, et al. An international roadmap for tuberculosis research: towards a world free of tuberculosis. WHO Libr Cat Data. 2011; 1-80.
28. Government of India. India takes a lead in TB research in a unique mission mode to End TB. [Internet]. 2016. p. 10-11.
29. Kritski A, Barreira D, Junqueira-Kipnis AP, Moraes MO, Campos MM, Degrave WM, et al. Brazilian response to global end TB strategy: the national tuberculosis research agenda. Rev Soc Bras Med Trop. 2016; 49(1): 135-45.
30. Samrc. Ship TB projects 2014 SAMRC contact details. 2014. [cited 2019 September 10]. Available from:
31. Sciencemag. Science is a major plank in China’s new spending plan [Internet]. Science. [cited 2019 September 2019]. 2016. Available from:

Financial support: Dr IA received funds for this work as a post-doc scholarship from the National Science and Technology Institute for Tuberculosis (CNPq/INCT 465318/2014-2).
+ Corresponding author:
Received 10 September 2019
Accepted 05 February 2020

Citation: Castor K, Mota FB, da Silva RM, Cabral BP, Maciel EL, de Almeida IN, et al. Mapping the tuberculosis scientific landscape among BRICS countries: a bibliometric and network analysis. Mem Inst Oswaldo Cruz. 2020; 115: e190342.

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