Mem Inst Oswaldo Cruz, Rio de Janeiro, VOLUME 118 | 2023
Perspective
Enterovirus infection and its relationship with neurodegenerative diseases
1Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Virologia Molecular, Rio de Janeiro, RJ, Brasil
2Universidade Federal do Rio de Janeiro, Instituto Nacional de Ciência e Tecnologia em Biologia Estrutural e Bioimagem, Instituto de Bioquímica Médica Leopoldo de Meis, Programa de Biologia Estrutural, Rio de Janeiro, RJ, Brasil
DOI: 10.1590/0074-02760220252
ABSTRACT
Neurodegenerative diseases (NDs) are increasingly common, especially in populations with higher life expectancies. They are associated mainly with protein metabolism and structure changes, leading to neuronal cell death. Viral infections affect these cellular processes and may be involved in the etiology of several neurological illnesses, particularly NDs. Enteroviruses (EVs) frequently infect the central nervous system (CNS), causing neurological disease. Inflammation, disruption of the host autophagy machinery, and deregulation and accumulation/misfolding of proteins are the main alterations observed after infection by an EV. In this perspective, we discuss the most recent findings on the subject, examining the possible role of EVs in the development of NDs, and shedding light on the putative role played by these viruses in developing NDs.
key words:
enterovirus
neurodegenerative diseases
amyotrophic lateral sclerosis
Alzheimer’s disease
Parkinson’s disease
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Financial support: CAPES, FAPERJ, FIOCRUZ, CNPq.
+ Corresponding author: ivanildo.sousa@ioc.fiocruz.br 
https://orcid.org/ 0000-0003-1840-3302
Received 31 October 2022
Accepted 24 January 2023
HOW TO CITE
Sousa Jr IP, Vieira TCRG. Enterovirus infection and its relationship with neurodegenerative diseases. Mem Inst Oswaldo Cruz. 2023; 118: e220252.
