Mem Inst Oswaldo Cruz, Rio de Janeiro, VOLUME 119 | 2024
Review
Worldwide distribution, symptoms and diagnosis of the coinfections between malaria and arboviral diseases: a systematic review
1Universidade Federal Fluminense, Centro de Investigação de Microrganismos, Instituto Biomédico, Departamento de Microbiologia e Parasitologia, Niterói, RJ, Brasil
2Universidade Federal Fluminense, Instituto Biomédico, Departamento de Microbiologia e Parasitologia, Programa de Pós-Graduação em Microbiologia e Parasitologia Aplicadas, Niterói, RJ, Brasil
3Universidade Federal Fluminense, Programa de Pós-Graduação em Ciências e Biotecnologia, Niterói, RJ, Brasil
4Universidade Federal de Sergipe, Centro de Ciências Biológicas e da Saúde, Departamento de Biologia, Programa de Pós-Graduação em Biologia Parasitária, São Cristóvão, SE, Brasil
DOI: 10.1590/0074-02760240015
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ABSTRACT
The coinfection between malaria (ML) and arboviral diseases represents a major global public health problem, particularly in tropical and subtropical countries. Despite its relevance, this topic is still insufficiently discussed in the current literature. Here, we aimed to investigate the worldwide distribution, symptoms, and diagnosis during coinfection between ML and arboviral diseases. We conducted a systematic review following the Preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement and assessed the selection and eligibility criteria, created and diagrammed maps, and analysed major symptoms with 95% confidence intervals (CI) using prevalence ratio and effect size, also performing latent class analysis. A total of 85,485 studies were retrieved, of which 56 were included: 57.14% in Asia, 25% in Africa, 14.30% in South America, and 3.56% in Europe. A total of 746 individuals were reported to be coinfected with Plasmodium and arbovirus. Concurrent ML, Dengue (DEN), Chikungunya (CHIK), and Zika (ZIK) patients are more likely to present headache and skin rash. Regarding diagnosis, 58,253 were made, of which 38,176 were positive (ML and at least one arboviral disease). The magnitude of these pathogens’ coexistence points out the pressing need for improvements in public health policies towards diagnosis and prevention of both diseases, especially in endemic areas.
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Financial support: CAPES (Finance code: 001), CNPq, FAPERJ.
MCF, ESM, MPS and NFR were supported by a CAPES fellowship; MCSJ, ARSB and RLDM were supported by a CNPq fellowship.
MCF, MLA and ESM contributed equally to this work.
+ Corresponding authors: mcerilo@id.uff.br / ricardomachado@id.uff.br 
https://orcid.org/0000-0002-4221-2728 https://orcid.org/0000-0002-8955-3204
Received 20 January 2024
Accepted 02 May 2024
HOW TO CITE
Cerilo-Filho M, Arouca ML, Medeiros ES, de Jesus MCS, Sampaio MP, Reis NF, et al. Worldwide distribution, symptoms and diagnosis of the coinfections between malaria and arboviral diseases: a systematic review. Mem Inst Oswaldo Cruz. 2024; 119: e240015.
