REFERENCES

01. MS - Ministério da Saúde. Situação epidemiológica da leishmaniose visceral. 2023 [cited 2024 Aug 8]. Available from: https:// www.gov.br/saude/pt-br/assuntos/saude-de-a-a-z/l/leishmaniosevisceral/ situacao-epidemiologica-da-leishmaniose-visceral.

02. PAHO - Pan American Health Organization. Leishmaniasis: epidemiological report of the Americas. 2023 [cited 2024 Aug 8]. Available from: https://iris.paho.org/handle/10665.2/56831.

03. WHO - World Health Organization. Chagas disease (American trypanosomiasis). 2023 [cited 2024 Aug 8]. Available from: https://www.who.int/health-topics/chagas-disease#tab=tab_1.

04. Coura JR, Borges-Pereira J. Chagas disease: what is known and what is needed — a background article. Acta Trop. 2013; 125(1): 5-13. doi:10.1016/j.actatropica.2013.10.002.

05. Hotez PJ, Dumonteil E, Cravioto MB, Bottazzi ME, Tapia-Conyer R, Meymandi S, et al. Chagas disease: the new HIV/AIDS of the Americas. N Engl J Med. 2012; 366(10): 949-56. doi:10.1056/ NEJMra064142.

06. PAHO - Pan American Health Organization. Leishmaniasis: general information. 2023 [cited 2025 Mar 26]. Available from: https://www.paho.org/en/topics/leishmaniasis.

07. Hide G. Gene amplification in Leishmania. J Biol Chem. 1999; 278(10): 7993-8000. doi:10.1128/cmr.12.1.112.

08. MS - Ministério da Saúde. National Health Agenda. 2023 [cited 2024 Aug 11]. Available from: https://bvsms.saude.gov.br/bvs/ publicacoes/agenda_ingles.pdf.

09. CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Evolução do SNPG no decênio do 2011-2020. 2022 [cited 2024 Aug 20]. Available from: https://www.gov.br/capes/ pt-br/centrais-de-conteudo/07032022_EvolucaodoSNPGnodeceniodoPNPG20112020_ ISBNWeb.pdf.

10. Wickham H, François R, Henry L, Müller K, Vaughan D. dplyr: a grammar of data manipulation. 2023 [cited 2024 Aug 26]. Available from: https://dplyr.tidyverse.org.

11. Wickham H. ggplot2: elegant graphics for data analysis. 2006 [cited 2025 Mar 26]. Available from: https://ggplot2.tidyverse.org.

12. Wickham H, Averick M, Bryan J, Chang W, McGowan L, François R, et al. Welcome to the tidyverse. J Open Source Softw. 2019; 4(42): 1686. doi:10.21105/joss.01686.

13. Bustamante MMC, Hipólito J, Delgado PGG, Ferrante L, Vale MM. The future of Brazilian science. Nat Hum Behav. 2023; 7(6): 825-7. doi:10.1038/s41562-023-01597-7.

14. Nature Portfolio. How Brazil’s resilient research ecosystem weathered funding cuts. 2023 [cited 2024 Aug 20]. Available from: https://www.nature.com/articles/d42473-023-00323-1.

15. Lopes MA, Oliveira DB. Research and publication in Brazil: where we are and where we head to. Int J Cardiovasc Sci. 2021; 34(2): 231-5. doi:10.36660/ijcs.20200004.

16. MS - Ministério da Educação. O que é REUNI? 2023 [cited 2024 Aug 11]. Available from: https://reuni.mec.gov.br/o-que-e-o-reuni.

17. MS - Ministério da Educação. Presidente Lula entrega campi de universidades e institutos federais. 2023 [cited 2024 Aug 26]. Available from: http://portal.mec.gov.br/ultimas-noticias/212- educacao-superior-1690610854/16096-presidente-lula-entregacampi- de-universidades-e-institutos-federais.

18. Isac IPG. Pesquisa e Pós-Graduação no Nordeste do Brasil: assimetrias na produção do conhecimento. In: XXXI Congreso de la Asociación Latinoamericana de Sociología. Montevideo. 2017 [cited 2024 Aug 11]. Available from: https://cdsa.aacademica. org/000-018/1320.pdf.

19. Castro AM, Oliveira L. Avaliação e expansão da pós-graduação em educação no Brasil e no Nordeste: assimetrias e desafios. Rev Educ Questão. 2021; 59(59): e24454. doi:10.21680/1981- 1802.2021v59n59ID24454.

20. CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Proposta de aprimoramento da avaliação da pós-graduação brasileira para o quadriênio 2021-2024 - modelo multidimensional. 2020 [cited 2024 Aug 26]. Available from: https://www. gov.br/capes/pt-br/centrais-de-conteudo/25052020-relatorio-final- 2019-comissao-pnpg-pdf.

21. Web of Science. A pesquisa no Brasil: promovendo a excelência. 2019 [cited 2024 Aug 11]. Available from: https://propp.ufms.br/ files/2019/09/Pesquisa-no-Brasil.pdf.

22. Barros ASX. Expansão da educação superior no Brasil: Limites e possibilidades. Educ Soc. 2015; 36(131): 361-90. doi:10.1590/ ES0101-7330201596208.

23. CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Plano Nacional de Pós-Graduação - PNPG 2011-2020. 2010 [cited 2025 Mar 26]. Available from: https://bibliotecadigital. economia.gov.br/bitstream/123456789/940/1/Livros-PNPGVolume- I-Mont.pdf.

24. Ribeiro AL, Lima MM, Xavier CC. The CUIDA Chagas Project: towards the elimination of congenital transmission of Chagas disease in Bolivia, Brazil, Colombia, and Paraguay. Rev Soc Bras Med Trop. 2022; 55: doi: 10.1590/0037-8682-0171-2021.

25. Menezes M. Fiocruz e Opas padronizam diagnóstico para leishmaniose cutânea nas Américas. Rio de Janeiro: Fundação Oswaldo Cruz. 2023 [cited 2025 Sep 3]. Available from: https://agencia. fiocruz.br/fiocruz-e-opas-padronizam-diagnostico-para-leishmaniose- cutanea-nas-americas.

Mem Inst Oswaldo Cruz, Rio de Janeiro, VOLUME 120 | 2025

Research Articles

Trypanosomatid research in Brazil: a systematic analysis of regional and temporal trends

Bárbara Marinho, Izabela Mamede, Júlia Raspante Martins, André Rodrigues, Ana Gabrielle Batista de Melo, Adalberto Sales Miranda-Junior, Alice Rios Neto, Amanda Carolina da Silva Nunes, Bruno Carvalho Resende, Dáfne Oliveira, Darlan Oliveira da Silva, Frederico Gabriel de Carvalho Oliveira, Jéssica Duarte, Lorrane Diniz de Carvalho Silva, Wesley Roger Rodrigues Ferreira, Daniela De Laet-Souza, Andrea Mara Macedo, Glória Regina Franco⁺, Carlos Renato Machado⁺

Universidade Federal de Minas Gerais, Instituto de Ciências Biológicas, Departamento de Bioquímica e Imunologia, Laboratório de Genética Bioquímica, Belo Horizonte, MG, Brasil

DOI: 10.1590/0074-02760250098

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ABSTRACT

BACKGROUND Trypanosomatid infections such as Chagas disease (CD) and leishmaniasis remain major public-health concerns. Brazil has a long tradition in this field, yet a consolidated, country-level view of outputs, impact and collaboration patterns is useful to guide scientific policy.
OBJECTIVES To characterise Brazilian scientific production on Trypanosoma cruzi, Leishmania and Trypanosoma brucei (2010-2021), describing temporal trends, regional contributions, collaboration networks and journal impact.
METHODS We performed a bibliometric analysis of PubMed records retrieved with Medical Subject Headings (MeSH) for each pathogen/disease pair, covering publications from 1 January 2010 to 31 December 2021 (search date: 21 July 2022). Data items included article type, year, journal, author affiliations (countries/institutions) and, for Brazil, the geographical region of the corresponding author. Descriptive statistics and visualisations were generated in R.
FINDINGS From 21,713 records, 6,478 were affiliated to Brazil. Brazil contributed a substantial share of the global literature, particularly for T. cruzi (≈40%) and Leishmania (≈30%). Within Brazil, output increased over time with growing participation from the north and northeast, alongside expanding inter-institutional and international collaborations. Most publications appeared in higher-impact journals (Q1/Q2), with recent gains in Q1 outputs in historically under-represented regions. Original research predominated over reviews across the period.
MAIN CONCLUSIONS Brazilian trypanosomatid research shows sustained growth, increasing regional dispersion and rising international engagement, with a strong presence in high-impact journals. Continued support for collaborative networks and equitable funding across regions could further enhance national and global impact.

key words: Trypanosoma cruzi Leishmania Brazil Tripanosomatids research bibliometrics

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