Mem Inst Oswaldo Cruz, Rio de Janeiro, 108(3) May 2013
Short communication
Oseltamivir-resistant influenza A(H1N1)pdm09 virus in southern Brazil
1Universidade Luterana do Brasil, Canoas, RS, Brasil
2Laboratório Central de Saúde Pública do Rio Grande do Sul, Porto Alegre, RS, Brasil
3Simbios Biotecnologia, Cachoeirinha, RS, Brasil
Page: 392-394
DOI: 10.1590/0074-0276108032013021
ABSTRACT
The neuraminidase (NA) genes of A(H1N1)pdm09 influenza virus isolates from 306 infected patients were analysed. The circulation of oseltamivir-resistant viruses in Brazil has not been reported previously. Clinical samples were collected in the state of Rio Grande do Sul (RS) from 2009-2011 and two NA inhibitor-resistant mutants were identified, one in 2009 (H275Y) and the other in 2011 (S247N). This study revealed a low prevalence of resistant viruses (0.8%) with no spread of the resistant mutants throughout RS.
