Mem Inst Oswaldo Cruz, Rio de Janeiro, 113(6) june 2018
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Plasmodium vivax malaria elimination: should innovative ideas from the past be revisited?

Fernando Fonseca Val1,2, Vanderson Souza Sampaio1,2, Maria Belén Cassera3, Raquel Tapajós Andrade1,2, Pedro Luiz Tauil4, Wuelton Marcelo Monteiro1,2, Marcus Vinícius Guimarães Lacerda1,2,+

1Gerência de Malária, Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, AM, Brasil
2Escola Superior de Ciências da Saúde, Universidade do Estado do Amazonas, Manaus, AM, Brasil
3Department of Biochemistry, Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA, USA
4Faculdade de Medicina, Universidade de Brasília, Brasília, DF, Brasil

Page: 522-524 DOI: 10.1590/0074-0276140240
625 views 164 downloads
ABSTRACT

In the 1950s, the strategy of adding chloroquine to food salt as a prophylaxis against malaria was considered to be a successful tool. However, with the development of Plasmodium resistance in the Brazilian Amazon, this control strategy was abandoned. More than 50 years later, asexual stage resistance can be avoided by screening for antimalarial drugs that have a selective action against gametocytes, thus old prophylactic measures can be revisited. The efficacy of the old methods should be tested as complementary tools for the elimination of malaria.

+ Corresponding author: marcuslacerda.br@gmail.com
Received 9 July 2014
Accepted 25 July 2014

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