Mem Inst Oswaldo Cruz, Rio de Janeiro, 113(6) june 2018
Plasmodium vivax malaria elimination: should innovative ideas from the past be revisited?
1Gerência de Malária, Fundação de Medicina Tropical Dr Heitor Vieira Dourado, Manaus, AM, Brasil
2Escola Superior de Ciências da Saúde, Universidade do Estado do Amazonas, Manaus, AM, Brasil
3Department of Biochemistry, Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA, USA
4Faculdade de Medicina, Universidade de Brasília, Brasília, DF, Brasil
In the 1950s, the strategy of adding chloroquine to food salt as a prophylaxis against malaria was considered to be a successful tool. However, with the development of Plasmodium resistance in the Brazilian Amazon, this control strategy was abandoned. More than 50 years later, asexual stage resistance can be avoided by screening for antimalarial drugs that have a selective action against gametocytes, thus old prophylactic measures can be revisited. The efficacy of the old methods should be tested as complementary tools for the elimination of malaria.