Mem Inst Oswaldo Cruz, Rio de Janeiro, VOLUME 114 | FEB 2019
Short communication

Development of Leishmania mexicana in Lutzomyia longipalpis in the absence of sugar feeding

Samara G da Costa1, Caroline da Silva Moraes1, Paul Bates2, Rod Dillon2,3, Fernando Ariel Genta1,3,+

1Fundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Bioquímica e Fisiologia de Insetos, Rio de Janeiro, RJ, Brasil
2Lancaster University, Faculty of Health and Medicine, Division of Biomedical and Life Sciences, Lancaster, United Kingdom
3Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular, Rio de Janeiro, RJ, Brasil

DOI: 10.1590/0074-02760180482
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ABSTRACT

The leishmaniases are caused by Leishmania parasites and transmitted through the bites of phlebotomine sand flies. During parasite development inside the vector’s midgut, promastigotes move towards the stomodeal valve, a mechanism that is crucial for transmission. It has been reported that the sugar meal acquired by sand flies during feeding between bloodmeals is essential for the development and migration of parasites. We demonstrated that the distribution of Leishmania mexicana parasites was affected by the sugar meals obtained by the sand flies. Promastigote migration towards the cardia region seems to be only partially based on the stimuli provided by sugar molecules. In the absence of sugars, significant amounts of parasites developed in the hindgut. In addition, sugar meals were important for the survival of sand flies, especially during blood digestion, presumably supporting their energy requirements.

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Financial support: FAPERJ, CNPq, CAPES, FIOCRUZ.
SGC received a sandwich PhD grant from Science without Borders (CNPq/CAPES); CSM is a Postdoc from PNPD (CAPES/FAPERJ) and received a grant from Science without Borders (CNPq/CAPES).
+ Corresponding author: genta@ioc.fiocruz.br / gentafernando@gmail.com
https://orcid.org/0000-0001-9558-1116
Received 14 October 2018
Accepted 4 February 2019

Citation: da Costa SG, Moraes CS, Bates P, Dillon R, Genta FA. Development of Leishmania mexicana in Lutzomyia longipalpis in the absence of sugar feeding. Mem Inst Oswaldo Cruz. 2019; 114: e180482.

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